A couple love their new house, bought for a steal out of a foreclosure. During their first visit they find illegal drugs stashed in the walls, and they realize this is not their dream house. As they are about to leave, suddenly their exit is blocked by a gun-wielding neighbor Spector and his accomplice. They come to realize the house is hiding more than drugs - it's the operation center for mass drug czar who is buried beneath the floorboards. On the run from the professional killers who want the drugs and evidence, the resourceful couple will need to turn the tables on their attackers to survive.

Ray Bradstone (Levesque) is the best wheel man in the business, but he is determined to go straight and be the best parent he can be to his daughter, Sally (Winter), and make amends with his ex-wife, Lynne (Gish). As Ray struggles to find honest work, his old bank-robbing crew, led by Phillip Larue (Corrigan), offers him one last job. He agrees at first, but changes his mind at the last second leaving the crew without a driver. Ray decides instead to serve as a chaperone for Sally's school field trip. When the robbery goes awry, Larue blames Ray and chases the school bus all the way to the Museum of Natural History in New Orleans. Ray must deal with Larue, while supervising Sally's class on what becomes one of the craziest school trips ever.